The Omega “Sweetheart Song,” with words and music by Don Q. Pullen, was adopted as the official sweetheart song by the 1940 Nashville Grand Conclave.

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Founder Ernest E. Just entered Omega chapter in 1941.

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In 1941, Brother Charles Drew perfects the use of blood plasma as a life-saving tool. Brother William Hastie resigns as Civilian Aide to the Secretary of War in protest against discrimination in the armed forces. He was later appointed Governor of the Virgin Islands by President Harry S. Truman.

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Since 1945, the fraternity undertook a National Social Action program to meet the needs of African Americans in the areas of health, housing, civil rights, and education. The office of Second Vice Grand Basileus is created. Dexter Eure, of Theta Psi chapter, is elected to the position on the Supreme Council.

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In 1949, the first National Headquarters Building located at 107 Rhode Island Avenue, N.W., Washington, D.C. was purchased.

H. Carl Moultrie was selected to serve as the first National Executive Secretary. That same year, the scholarship fund was renamed in honor of Charles R. Drew.